| 🇺🇸AlbanyALB | American Airlines | — | 1x weekly | 1,975 km | Details |
| 🇳🇱AmsterdamAMS | Qatar Airways, KLM | — | 5x weekly | 7,443 km | Details |
| 🇺🇸AnchorageANC | Atlas Air | — | 1x weekly | 6,435 km | Details |
| 🇺🇸AtlantaATL | Atlas Air, Frontier Airlines, Delta Air Lines +2 | — | Daily+ | 959 km | Details |
| 🇺🇸AustinAUS | American Airlines, Delta Air Lines, Southwest Airlines | — | Daily+ | 1,772 km | Details |
| 🇺🇸BaltimoreBWI | Frontier Airlines, Southwest Airlines, American Airlines | — | Daily+ | 1,526 km | Details |
| 🇪🇸BarcelonaBCN | American Airlines, Iberia, Miami Air International | — | 11x weekly | 7,545 km | Details |
| 🇨🇴BarranquillaBAQ | American Airlines, Avianca | — | Daily+ | 1,756 km | Details |
| 🇰🇳BasseterreSKB | American Airlines | — | 9x weekly | 2,044 km | Details |
| 🇻🇬Beef IslandEIS | American Airlines | — | Daily+ | 1,814 km | Details |
| 🇧🇷BelémBEL | Gol | — | 2x weekly | 4,562 km | Details |
| 🇧🇿Belize CityBZE | American Airlines | — | Daily+ | 1,236 km | Details |
| 🇺🇸BirminghamBHM | American Airlines | — | 8x weekly | 1,065 km | Details |
| 🇨🇴BogotaBOG | Avianca, American Airlines, Emirates +1 | — | Daily+ | 2,435 km | Details |
| 🇯🇲BoscobelOCJ | American Airlines | — | 9x weekly | 890 km | Details |
| 🇺🇸BostonBOS | American Airlines, Delta Air Lines, Spirit Airlines | — | Daily+ | 2,028 km | Details |
| 🇧🇷BrasíliaBSB | Gol | — | 9x weekly | 5,808 km | Details |
| 🇧🇧BridgetownBGI | American Airlines | — | Daily+ | 2,593 km | Details |
| 🇦🇷Buenos Aires (Ezeiza)EZE | American Airlines, Aerolineas Argentinas, LATAM | — | Daily+ | 7,119 km | Details |
| 🇺🇸BuffaloBUF | American Airlines | — | 1x weekly | 1,912 km | Details |
| 🇨🇴CaliCLO | American Airlines | — | 8x weekly | 2,509 km | Details |
| 🇨🇺CamagueyCMW | American Airlines | — | 9x weekly | 546 km | Details |
| 🇲🇽CancúnCUN | American Airlines, Aeromexico, LATAM | — | Daily+ | 855 km | Details |
| 🇭🇹Cap HaitienCAP | Sunrise Airways | — | 9x weekly | 1,069 km | Details |
| 🇨🇴CartagenaCTG | American Airlines | — | Daily+ | 1,780 km | Details |
| 🇲🇦CasablancaCMN | Royal Air Maroc | — | 2x weekly | 6,941 km | Details |
| 🇺🇸Cedar RapidsCID | American Airlines | — | 1x weekly | 2,072 km | Details |
| 🇺🇸CharlestonCHS | National Airlines, American Airlines | — | Daily+ | 790 km | Details |
| 🇺🇸CharlotteCLT | American Airlines, Spirit Airlines, Frontier Airlines | — | Daily+ | 1,049 km | Details |
| 🇻🇮Charlotte AmalieSTT | American Airlines | — | Daily+ | 1,781 km | Details |
| 🇺🇸ChattanoogaCHA | American Airlines | — | 1x weekly | 1,130 km | Details |
| 🇺🇸ChicagoORD | American Airlines, Spirit Airlines, Frontier Airlines +1 | — | Daily+ | 1,930 km | Details |
| 🇺🇸ChicagoMDW | Southwest Airlines | — | 10x weekly | 1,905 km | Details |
| 🇻🇮ChristianstedSTX | American Airlines | — | Daily+ | 1,833 km | Details |
| 🇨🇺CienfuegosCFG | IBC Airways | — | 1x weekly | 406 km | Details |
| 🇺🇸Cincinnati / CovingtonCVG | 21 Air, American Airlines, Frontier Airlines | — | Daily+ | 1,529 km | Details |
| 🇺🇾Ciudad de la CostaMVD | American Airlines | — | 8x weekly | 7,210 km | Details |
| 🇺🇸ClevelandCLE | American Airlines, Frontier Airlines | — | Daily+ | 1,742 km | Details |
| 🇺🇸ColumbusCMH | Southwest Airlines, American Airlines | — | Daily+ | 1,598 km | Details |
| 🇩🇰CopenhagenCPH | SAS | — | Daily | 7,845 km | Details |
| 🇭🇳Coxen HoleRTB | American Airlines | — | 9x weekly | 1,236 km | Details |
| 🇲🇽CozumelCZM | American Airlines | — | 8x weekly | 897 km | Details |
| 🇺🇸DallasDAL | Southwest Airlines | — | 8x weekly | 1,783 km | Details |
| 🇺🇸Dallas-Fort WorthDFW | American Airlines, Frontier Airlines, Spirit Airlines | — | Daily+ | 1,802 km | Details |
| 🇺🇸DenverDEN | Frontier Airlines, United Airlines, Southwest Airlines +1 | — | Daily+ | 2,749 km | Details |
| 🇺🇸Des MoinesDSM | American Airlines | — | 8x weekly | 2,137 km | Details |
| 🇺🇸DetroitDTW | Frontier Airlines, Delta Air Lines, American Airlines +1 | — | Daily+ | 1,847 km | Details |
| 🇶🇦DohaDOH | Qatar Airways | — | 11x weekly | 12,340 km | Details |
| 🇦🇪DubaiDXB | Emirates | — | 9x weekly | 12,607 km | Details |
| 🇮🇪DublinDUB | Aer Lingus | — | 3x weekly | 6,693 km | Details |
| 🇺🇸DullesIAD | United Airlines, Frontier Airlines | — | Daily+ | 1,486 km | Details |
| 🇺🇸EagleEGE | American Airlines | — | 9x weekly | 2,911 km | Details |
| 🇺🇸Fayetteville/Springdale/RogersXNA | American Airlines | — | 8x weekly | 1,769 km | Details |
| 🇲🇶Fort-de-FranceFDF | American Airlines | — | 3x weekly | 2,362 km | Details |
| 🇩🇪Frankfurt am MainFRA | Lufthansa | — | 8x weekly | 7,763 km | Details |
| 🇧🇸FreeportFPO | American Airlines | — | Daily+ | 180 km | Details |
| 🇺🇸GainesvilleGNV | American Airlines | — | 9x weekly | 475 km | Details |
| 🇰🇾George TownGCM | Cayman Airways, American Airlines | — | Daily+ | 731 km | Details |
| 🇬🇾GeorgetownGEO | Surinam Airways | — | 3x weekly | 3,174 km | Details |
| 🇧🇸Governor's HarbourGHB | American Airlines | — | 9x weekly | 401 km | Details |
| 🇺🇸Grand RapidsGRR | American Airlines | — | 8x weekly | 1,958 km | Details |
| 🇺🇸GreensboroGSO | American Airlines | — | 8x weekly | 1,146 km | Details |
| 🇺🇸Greenville/Greer/SpartanburgGSP | American Airlines | — | Daily+ | 1,029 km | Details |
| 🇲🇽GuadalajaraGDL | Volaris | — | 5x weekly | 2,422 km | Details |
| 🇬🇹Guatemala CityGUA | American Airlines | — | Daily+ | 1,640 km | Details |
| 🇪🇨GuayaquilGYE | LATAM Ecuador, Avianca, Avianca Ecuador +1 | — | Daily+ | 3,109 km | Details |
| 🇧🇲HamiltonBDA | American Airlines | — | 8x weekly | 1,681 km | Details |
| 🇺🇸HarrisburgMDT | American Airlines | — | 1x weekly | 1,634 km | Details |
| 🇺🇸HartfordBDL | American Airlines | — | 8x weekly | 1,925 km | Details |
| 🇨🇺HavanaHAV | American Airlines, Delta Air Lines | — | Daily+ | 379 km | Details |
| 🇫🇮Helsinki (Vantaa)HEL | Finnair | — | 4x weekly | 8,327 km | Details |
| 🇨🇺HolguinHOG | American Airlines | — | 8x weekly | 689 km | Details |
| 🇺🇸HoustonIAH | United Airlines, American Airlines, Spirit Airlines +1 | — | Daily+ | 1,549 km | Details |
| 🇺🇸HoustonHOU | Southwest Airlines | — | 1x weekly | 1,535 km | Details |
| 🇺🇸HuntsvilleHSV | American Airlines | — | 1x weekly | 1,163 km | Details |
| 🇺🇸IndianapolisIND | American Airlines, Southwest Airlines | — | Daily+ | 1,646 km | Details |
| 🇹🇷IstanbulIST | Turkish Airlines | — | Daily+ | 9,583 km | Details |
| 🇺🇸JacksonvilleJAX | American Airlines | — | Daily+ | 540 km | Details |
| 🇺🇸Kansas CityMCI | Southwest Airlines, American Airlines | — | Daily+ | 2,015 km | Details |
| 🇺🇸Key WestEYW | American Airlines | — | Daily+ | 202 km | Details |
| 🇯🇲KingstonKIN | American Airlines | — | Daily+ | 946 km | Details |
| 🇻🇨KingstownSVD | American Airlines | — | Daily | 2,444 km | Details |
| 🇺🇸Knoxville/MaryvilleTYS | American Airlines | — | 8x weekly | 1,168 km | Details |
| 🇧🇶KralendijkBON | American Airlines | — | 6x weekly | 1,974 km | Details |
| 🇩🇴La RomanaLRM | American Airlines | — | 6x weekly | 1,427 km | Details |
| 🇺🇸Las VegasLAS | American Airlines | — | Daily+ | 3,494 km | Details |
| 🇭🇹Les CayesCYA | IBC Airways | — | 1x weekly | 1,072 km | Details |
| 🇺🇸LexingtonLEX | American Airlines | — | 1x weekly | 1,420 km | Details |
| 🇨🇷LiberiaLIR | American Airlines | — | Daily+ | 1,779 km | Details |
| 🇵🇪LimaLIM | Sky Airline, American Airlines, LATAM | — | Daily+ | 4,219 km | Details |
| 🇵🇹LisbonLIS | TAP Air Portugal | — | 11x weekly | 6,677 km | Details |
| 🇺🇸Little RockLIT | American Airlines | — | 1x weekly | 1,515 km | Details |
| 🇬🇧LondonLHR | British Airways, American Airlines, Virgin Atlantic | — | Daily+ | 7,109 km | Details |
| 🇺🇸Los AngelesLAX | American Airlines, Delta Air Lines, United Airlines | — | Daily+ | 3,763 km | Details |
| 🇺🇸LouisvilleSDF | American Airlines | — | 8x weekly | 1,468 km | Details |
| 🇳🇱MaastrichtMST | Turkish Airlines | — | 1x weekly | 7,546 km | Details |
| 🇺🇸MadisonMSN | American Airlines | — | 1x weekly | 2,096 km | Details |
| 🇪🇸MadridMAD | Iberia, Air Europa, American Airlines | — | Daily+ | 7,106 km | Details |
| 🇳🇮ManaguaMGA | American Airlines, Avianca | — | Daily+ | 1,639 km | Details |
| 🇩🇲MarigotDOM | American Airlines | — | Daily+ | 2,276 km | Details |
| 🇧🇸Marsh HarbourMHH | American Airlines | — | Daily+ | 330 km | Details |
| 🇨🇺MatanzasVRA | American Airlines | — | Daily | 328 km | Details |
| 🇨🇴MedellínMDE | Avianca, American Airlines | — | Daily+ | 2,243 km | Details |
| 🇺🇸MemphisMEM | American Airlines | — | 8x weekly | 1,384 km | Details |
| 🇲🇽MéridaMID | American Airlines, VivaAerobus | — | 10x weekly | 1,097 km | Details |
| 🇲🇽Mexico CityMEX | Aeromexico, American Airlines, Volaris | — | Daily+ | 2,051 km | Details |
| 🇺🇸MilwaukeeMKE | American Airlines, Southwest Airlines | — | 10x weekly | 2,029 km | Details |
| 🇺🇸MinneapolisMSP | Delta Air Lines, American Airlines, Sun Country Airlines | — | Daily+ | 2,418 km | Details |
| 🇯🇲Montego BayMBJ | American Airlines, IBC Airways | — | Daily+ | 847 km | Details |
| 🇲🇽MonterreyMTY | VivaAerobus, American Airlines | — | 11x weekly | 1,982 km | Details |
| 🇨🇦MontréalYUL | Air Canada, American Airlines | — | Daily+ | 2,264 km | Details |
| 🇧🇸Moss TownGGT | American Airlines | — | Daily+ | 510 km | Details |
| 🇩🇪MunichMUC | Lufthansa | — | 8x weekly | 8,043 km | Details |
| 🇺🇸NashvilleBNA | American Airlines, Southwest Airlines | — | Daily+ | 1,299 km | Details |
| 🇧🇸NassauNAS | American Airlines, Bahamasair, IBC Airways | — | Daily+ | 296 km | Details |
| 🇺🇸New OrleansMSY | American Airlines | — | Daily+ | 1,085 km | Details |
| 🇺🇸New YorkLGA | Spirit Airlines, Delta Air Lines, United Airlines | — | Daily+ | 1,768 km | Details |
| 🇺🇸New YorkJFK | Frontier Airlines, American Airlines | — | Daily+ | 1,757 km | Details |
| 🇺🇸NewarkEWR | United Airlines, American Airlines, Spirit Airlines | — | Daily+ | 1,750 km | Details |
| 🇺🇸NorfolkORF | American Airlines | — | Daily+ | 1,293 km | Details |
| 🇧🇸North EleutheraELH | American Airlines | — | Daily+ | 364 km | Details |
| 🇺🇸Oklahoma CityOKC | American Airlines | — | 8x weekly | 1,966 km | Details |
| 🇺🇸OmahaOMA | American Airlines | — | 10x weekly | 2,243 km | Details |
| 🇦🇼OranjestadAUA | American Airlines | — | Daily+ | 1,828 km | Details |
| 🇺🇸OrlandoMCO | American Airlines, Southwest Airlines | — | Daily+ | 310 km | Details |
| 🇦🇬OsbournANU | American Airlines | — | Daily+ | 2,139 km | Details |
| 🇨🇦OttawaYOW | Porter Airlines | — | 4x weekly | 2,210 km | Details |
| 🇭🇳PalmerolaXPL | American Airlines | — | Daily+ | 1,481 km | Details |
| 🇫🇷Paris (Orly, Val-de-Marne)ORY | French Bee | — | 3x weekly | 7,366 km | Details |
| 🇫🇷Paris (Roissy-en-France, Val-d'Oise)CDG | American Airlines, Air France | — | Daily+ | 7,372 km | Details |
| 🇺🇸PensacolaPNS | American Airlines | — | Daily+ | 853 km | Details |
| 🇺🇸PhiladelphiaPHL | American Airlines, Frontier Airlines, Spirit Airlines | — | Daily+ | 1,634 km | Details |
| 🇺🇸PhoenixPHX | American Airlines | — | Daily+ | 3,168 km | Details |
| 🇺🇸PittsburghPIT | Southwest Airlines, American Airlines | — | Daily+ | 1,634 km | Details |
| 🇬🇵Pointe-à-PitrePTP | Air France, American Airlines | — | 5x weekly | 2,213 km | Details |
| 🇹🇹Port of SpainPOS | American Airlines, Caribbean Airlines | — | Daily+ | 2,613 km | Details |
| 🇺🇸PortlandPDX | Alaska Airlines, American Airlines | — | Daily+ | 4,340 km | Details |
| 🇹🇨ProvidencialesPLS | American Airlines, IBC Airways | — | Daily+ | 930 km | Details |
| 🇩🇴Puerto PlataPOP | American Airlines | — | 9x weekly | 1,201 km | Details |
| 🇩🇴Punta CanaPUJ | LATAM, American Airlines, Arajet | — | Daily+ | 1,466 km | Details |
| 🇪🇨QuitoUIO | LATAM, LATAM Ecuador, American Airlines | — | Daily+ | 2,890 km | Details |
| 🇺🇸Raleigh/DurhamRDU | American Airlines, Frontier Airlines, Delta Air Lines | — | Daily+ | 1,130 km | Details |
| 🇮🇸ReykjavíkKEF | Icelandair | — | 3x weekly | 5,890 km | Details |
| 🇺🇸RichmondRIC | American Airlines | — | Daily+ | 1,332 km | Details |
| 🇧🇷Rio De JaneiroGIG | American Airlines | — | 11x weekly | 6,717 km | Details |
| 🇺🇸RochesterROC | American Airlines | — | 1x weekly | 1,941 km | Details |
| 🇮🇹RomeFCO | ITA Airways | — | 8x weekly | 8,330 km | Details |
| 🇬🇩Saint George'sGND | American Airlines | — | 8x weekly | 2,472 km | Details |
| 🇺🇸Salt Lake CitySLC | Delta Air Lines, American Airlines | — | Daily+ | 3,357 km | Details |
| 🇺🇸San AntonioSAT | American Airlines | — | 8x weekly | 1,836 km | Details |
| 🇺🇸San DiegoSAN | American Airlines | — | Daily+ | 3,643 km | Details |
| 🇺🇸San FranciscoSFO | American Airlines, United Airlines | — | Daily+ | 4,154 km | Details |
| 🇨🇷San José (Alajuela)SJO | American Airlines, Avianca, Vuela El Salvador +1 | — | Daily+ | 1,805 km | Details |
| 🇵🇷San JuanSJU | American Airlines, Frontier Airlines, Spirit Airlines | — | Daily+ | 1,682 km | Details |
| 🇭🇳San Pedro SulaSAP | American Airlines, Vuela El Salvador | — | 13x weekly | 1,397 km | Details |
| 🇧🇸San SalvadorZSA | Bahamasair, American Airlines | — | 4x weekly | 612 km | Details |
| 🇸🇻San Salvador (San Luis Talpa)SAL | American Airlines, Avianca, Vuela El Salvador | — | Daily+ | 1,651 km | Details |
| 🇨🇺Santa ClaraSNU | American Airlines | — | 1x weekly | 369 km | Details |
| 🇧🇴Santa CruzVVI | BoA | — | 6x weekly | 5,174 km | Details |
| 🇨🇱SantiagoSCL | LATAM | — | 13x weekly | 6,658 km | Details |
| 🇨🇺SantiagoSCU | American Airlines | — | 6x weekly | 792 km | Details |
| 🇩🇴Santo DomingoSDQ | American Airlines, Arajet | — | Daily+ | 1,366 km | Details |
| 🇧🇷São PauloGRU | LATAM, American Airlines | — | Daily+ | 6,574 km | Details |
| 🇺🇸Sarasota/BradentonSRQ | American Airlines | — | 13x weekly | 287 km | Details |
| 🇺🇸SavannahSAV | American Airlines | — | Daily+ | 709 km | Details |
| 🇺🇸SeattleSEA | Alaska Airlines, Delta Air Lines, American Airlines | — | Daily+ | 4,379 km | Details |
| 🇸🇽Sint MaartenSXM | American Airlines | — | Daily+ | 1,968 km | Details |
| 🇧🇸South BiminiBIM | American Airlines | — | 4x weekly | 103 km | Details |
| 🇺🇸SpringfieldSGF | American Airlines | — | 1x weekly | 1,775 km | Details |
| 🇺🇸St LouisSTL | American Airlines, Southwest Airlines | — | Daily+ | 1,721 km | Details |
| 🇸🇪StockholmARN | SAS | — | 1x weekly | 7,996 km | Details |
| 🇺🇸SyracuseSYR | American Airlines | — | 1x weekly | 1,963 km | Details |
| 🇺🇸TallahasseeTLH | American Airlines | — | Daily+ | 649 km | Details |
| 🇺🇸TampaTPA | American Airlines | — | Daily+ | 329 km | Details |
| 🇮🇱Tel AvivTLV | El Al | — | 6x weekly | 10,608 km | Details |
| 🇦🇮The ValleyAXA | American Airlines | — | Daily+ | 1,965 km | Details |
| 🇵🇦TocumenPTY | Copa Airlines, American Airlines | — | Daily+ | 1,862 km | Details |
| 🇨🇦TorontoYYZ | Air Canada, American Airlines, Porter Airlines | — | Daily+ | 1,989 km | Details |
| 🇺🇸TulsaTUL | American Airlines | — | 1x weekly | 1,879 km | Details |
| 🇺🇸ValparaisoVPS | American Airlines | — | 8x weekly | 802 km | Details |
| 🇨🇦VancouverYVR | Air Canada | — | 5x weekly | 4,503 km | Details |
| 🇱🇨Vieux FortUVF | American Airlines | — | Daily+ | 2,422 km | Details |
| 🇵🇱WarsawWAW | LOT - Polish Airlines | — | 5x weekly | 8,490 km | Details |
| 🇺🇸WashingtonDCA | American Airlines, Delta Air Lines | — | Daily+ | 1,483 km | Details |
| 🇰🇾West EndCYB | Cayman Airways | — | 1x weekly | 681 km | Details |
| 🇺🇸White PlainsHPN | American Airlines | — | 8x weekly | 1,803 km | Details |
| 🇨🇼WillemstadCUR | American Airlines, Surinam Airways | — | Daily+ | 1,923 km | Details |
| 🇺🇸WilmingtonILM | American Airlines | — | 8x weekly | 970 km | Details |
| 🇨🇭ZurichZRH | SWISS | — | Daily+ | 7,845 km | Details |
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